Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.

Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.

Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH protein (1 mg/kg) had no effect on spontaneou...

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Bibliographic Details
Main Authors: Marilyn E Carroll, Natalie E Zlebnik, Justin J Anker, Thomas R Kosten, Frank M Orson, Xiaoyun Shen, Berma Kinsey, Robin J Parks, Yang Gao, Stephen Brimijoin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3422258?pdf=render

Internet

http://europepmc.org/articles/PMC3422258?pdf=render

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