Pirfenidone Reduces Epithelial–Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts (CAFs)

Pirfenidone Reduces Epithelial–Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts (CAFs)

The aim of this study was to assess the effects of pirfenidone (PFD) on promoting epithelial–mesenchymal-transition (EMT) and stemness features in breast carcinoma cells through targeting cancer-associated-fibroblasts (CAFs). Using The Cancer Genome Atlas (TCGA) database, we analyzed the association...

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Bibliographic Details
Main Authors: Hamidreza Aboulkheyr Es, Thomas R Cox, Ehsan Sarafraz-Yazdi, Jean Paul Thiery, Majid Ebrahimi Warkiani
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
tumor microenvironment (TME)
cancer-associated fibroblasts (CAFs)
epithelial–mesenchymal transition (EMT)
pirfenidone (PFD)
3D microfluidic device
Online Access:https://www.mdpi.com/2072-6694/13/20/5118

Internet

https://www.mdpi.com/2072-6694/13/20/5118

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