Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis

Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis

Abstract Background Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, prednisone and methotrexate (MTX) are the most common anti-inflammatory t...

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Bibliographic Details
Main Authors: Raisa Kraaijvanger, Montse Janssen Bonás, Jan C. Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P. V. de Kleijn, Coline H. M. van Moorsel
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Respiratory Research
Subjects:
Extracellular vesicles
Sarcoidosis
Biomarkers
Therapy
Online Access:https://doi.org/10.1186/s12931-024-02809-y

Internet

https://doi.org/10.1186/s12931-024-02809-y

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