Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling

Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling

Summary: Overdose acetaminophen (APAP) can cause acute liver injury (ALI), but the underlying mechanism remains undetermined. This study explored the role of hepatic Zinc Finger And BTB Domain Containing 22 (ZBTB22) in defense against APAP-mediated hepatotoxicity. The results showed that hepatic ZBT...

Full description

Bibliographic Details
Main Authors: Yingjian Chen, Tianqi Cui, Shaorong Xiao, Tianyao Li, Yadi Zhong, Kaijia Tang, Jingyi Guo, Shangyi Huang, Jiabing Chen, Jiayu Li, Qi Wang, Jiawen Huang, Huafeng Pan, Yong Gao
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Pharmacology
Molecular physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223003954

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223003954

Similar Items