M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2/NF-κB signaling axis

M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2/NF-κB signaling axis

Abstract Intervertebral disc degeneration (IVDD) is the primary factor contributing to low back pain (LBP). Unlike elderly patients, many young IVDD patients usually have a history of trauma or long-term abnormal stress, which may lead to local inflammatory reaction causing by immune cells, and ulti...

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Bibliographic Details
Main Authors: Chunyang Fan, Wei Wang, Zilin Yu, Jiale Wang, Wei Xu, Zhongwei Ji, Wei He, Di Hua, Wentao Wang, Linye Yao, Yongkang Deng, Dechun Geng, Xiexing Wu, Haiqing Mao
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Nanobiotechnology
Subjects:
Macrophage
Exosome
LCN2
Intervertebral disc degeneration
Cellular senescence
Online Access:https://doi.org/10.1186/s12951-024-02556-8

Internet

https://doi.org/10.1186/s12951-024-02556-8

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