Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease

Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease

Abnormal Glu release occurs in the spinal cord of SOD1G93A mice, a transgenic animal model for human ALS. Here we studied the mechanisms underlying Glu release in spinal cord nerve terminals of SOD1G93A mice at a pre-symptomatic disease stage (30 days) and found that the basal release of Glu was mor...

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Bibliographic Details
Main Authors: Tiziana Bonifacino, Laura Musazzi, Marco Milanese, Mara Seguini, Antonella Marte, Elena Gallia, Luca Cattaneo, Franco Onofri, Maurizio Popoli, Giambattista Bonanno
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Pre-symptomatic SOD1G93A mice
Excessive glutamate release
Glutamate excitotoxicity
Glutamate release mechanisms
Presynaptic proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301723

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http://www.sciencedirect.com/science/article/pii/S0969996116301723

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