Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells
Regulatory T cells (Tregs) play an indispensable role in the prevention of autoimmune disease, as interferon gamma (IFN) mediated, lethal autoimmunity occurs (in both mice and humans) in their absence. In addition, regulatory T cells have been implicated in preventing the onset of autoimmune and a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00469/full |
| _version_ | 1819274673117986816 |
|---|---|
| author | Joseph eLarkin Chulbul M. Ahmed Tenisha D. Wilson Howard M Johnson |
| author_facet | Joseph eLarkin Chulbul M. Ahmed Tenisha D. Wilson Howard M Johnson |
| author_sort | Joseph eLarkin |
| collection | DOAJ |
| description | Regulatory T cells (Tregs) play an indispensable role in the prevention of autoimmune disease, as interferon gamma (IFN) mediated, lethal autoimmunity occurs (in both mice and humans) in their absence. In addition, regulatory T cells have been implicated in preventing the onset of autoimmune and auto-inflammatory conditions associated with aberrant IFN signaling such as type 1 diabetes, lupus, and LPS mediated endotoxemia. Notably, suppressor of cytokine signaling 1 deficient (SOCS1-/-) mice also succumb to a lethal auto-inflammatory disease, dominated by excessive IFN signaling and bearing similar disease course kinetics to Treg deficient mice. Moreover SOCS1 deficiency has been implicated in lupus progression, and increased susceptibility to LPS mediated endotoxemia. Although it has been established that Tregs and SOCS1 play a critical role in the regulation of IFN signaling, and the prevention of lethal auto-inflammatory disease, the role of Treg/SOCS1 cross-talk in the regulation of IFN signaling has been essentially unexplored. This is especially pertinent as recent publications have implicated a role of SOCS1 in the stability of peripheral Tregs. This review will examine the emerging research findings implicating a critical role of the intersection of the SOCS1 and Treg regulatory pathways in the control of IFN gamma signaling and immune system function. |
| first_indexed | 2024-12-23T23:12:10Z |
| format | Article |
| id | doaj.art-3fa82b782ef64980bedb72f1b63d385b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T23:12:10Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3fa82b782ef64980bedb72f1b63d385b2022-12-21T17:26:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-12-01410.3389/fimmu.2013.0046969682Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cellsJoseph eLarkin0Chulbul M. Ahmed1Tenisha D. Wilson2Howard M Johnson3University of FloridaUniversity of FloridaUniversity of FloridaUniversity of FloridaRegulatory T cells (Tregs) play an indispensable role in the prevention of autoimmune disease, as interferon gamma (IFN) mediated, lethal autoimmunity occurs (in both mice and humans) in their absence. In addition, regulatory T cells have been implicated in preventing the onset of autoimmune and auto-inflammatory conditions associated with aberrant IFN signaling such as type 1 diabetes, lupus, and LPS mediated endotoxemia. Notably, suppressor of cytokine signaling 1 deficient (SOCS1-/-) mice also succumb to a lethal auto-inflammatory disease, dominated by excessive IFN signaling and bearing similar disease course kinetics to Treg deficient mice. Moreover SOCS1 deficiency has been implicated in lupus progression, and increased susceptibility to LPS mediated endotoxemia. Although it has been established that Tregs and SOCS1 play a critical role in the regulation of IFN signaling, and the prevention of lethal auto-inflammatory disease, the role of Treg/SOCS1 cross-talk in the regulation of IFN signaling has been essentially unexplored. This is especially pertinent as recent publications have implicated a role of SOCS1 in the stability of peripheral Tregs. This review will examine the emerging research findings implicating a critical role of the intersection of the SOCS1 and Treg regulatory pathways in the control of IFN gamma signaling and immune system function.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00469/fullAutoimmunityInflammationT cellslupusTolerance/Suppression/Anergy |
| spellingShingle | Joseph eLarkin Chulbul M. Ahmed Tenisha D. Wilson Howard M Johnson Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells Frontiers in Immunology Autoimmunity Inflammation T cells lupus Tolerance/Suppression/Anergy |
| title | Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells |
| title_full | Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells |
| title_fullStr | Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells |
| title_full_unstemmed | Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells |
| title_short | Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells |
| title_sort | regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory t cells |
| topic | Autoimmunity Inflammation T cells lupus Tolerance/Suppression/Anergy |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00469/full |
| work_keys_str_mv | AT josephelarkin regulationofinterferongammasignalingbysuppressorsofcytokinesignalingandregulatorytcells AT chulbulmahmed regulationofinterferongammasignalingbysuppressorsofcytokinesignalingandregulatorytcells AT tenishadwilson regulationofinterferongammasignalingbysuppressorsofcytokinesignalingandregulatorytcells AT howardmjohnson regulationofinterferongammasignalingbysuppressorsofcytokinesignalingandregulatorytcells |