Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation

Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation

The function of intracellular trafficking in immune-complex triggered inflammation remains poorly understood. Here, we investigated the role of Insulin-Regulated Amino Peptidase (IRAP)-positive endosomal compartments in Fc receptor (FcR)-induced inflammation. Less severe FcγR-triggered arthritis, ac...

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Bibliographic Details
Main Authors: Manuela Bratti, Shamila Vibhushan, Cyril Longé, Despoina Koumantou, Gaël Ménasché, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Loredana Saveanu, Sanae Ben Mkaddem
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Fc receptors
inflammation
signaling
intracellular trafficking
insulin-regulated aminopeptidase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1029759/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1029759/full

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