Cancer Progression Gene Expression Profiling Identifies the Urokinase Plasminogen Activator Receptor as a Biomarker of Metastasis in Cutaneous Squamous Cell Carcinoma

Cancer Progression Gene Expression Profiling Identifies the Urokinase Plasminogen Activator Receptor as a Biomarker of Metastasis in Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (cSCC) of the head and neck region is the second most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%–5% of cases. To further our understanding of the molecular events characterizing cSCC invasion and metastasis, we conducted targeted...

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Bibliographic Details
Main Authors: Elahe Minaei, Simon A. Mueller, Bruce Ashford, Amarinder Singh Thind, Jenny Mitchell, Jay R. Perry, Benjamin Genenger, Jonathan R. Clark, Ruta Gupta, Marie Ranson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
cutaneous squamous cell carcinoma (cSSC)
urokinase plasminogen activator receptor (uPAR)
urokinase plasminogen activator (uPA)
metastasis
matrix metalloproteinase (MMP)
extracellular matrix (ECM)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.835929/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.835929/full

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