Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.

Mutations in the glucosidase, beta, acid (GBA1) gene cause Gaucher's disease, and are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB) excluding variants of low penetrance. Because α-synuclein-containing neuronal aggregates are a defining...

Full description

Bibliographic Details
Main Authors: Marie Y Davis, Kien Trinh, Ruth E Thomas, Selina Yu, Alexandre A Germanos, Brittany N Whitley, Sergio Pablo Sardi, Thomas J Montine, Leo J Pallanck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4809718?pdf=render

Internet

http://europepmc.org/articles/PMC4809718?pdf=render

Similar Items