Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys
HIV infection results in the depletion of CD4+ T cells overtime and the loss of coordinated cellular immunity, but how this corresponds to the SIV infected African Green Monkey (AGM) model of non-progressive disease is not known. Here the authors assess the impact of experimental CD4+ T cell depleti...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36379-2 |
| _version_ | 1797864177855889408 |
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| author | Quentin Le Hingrat Paola Sette Cuiling Xu Andrew R. Rahmberg Lilas Tarnus Haritha Annapureddy Adam Kleinman Egidio Brocca-Cofano Ranjit Sivanandham Sindhuja Sivanandham Tianyu He Daniel J. Capreri Dongzhu Ma Jacob D. Estes Jason M. Brenchley Cristian Apetrei Ivona Pandrea |
| author_facet | Quentin Le Hingrat Paola Sette Cuiling Xu Andrew R. Rahmberg Lilas Tarnus Haritha Annapureddy Adam Kleinman Egidio Brocca-Cofano Ranjit Sivanandham Sindhuja Sivanandham Tianyu He Daniel J. Capreri Dongzhu Ma Jacob D. Estes Jason M. Brenchley Cristian Apetrei Ivona Pandrea |
| author_sort | Quentin Le Hingrat |
| collection | DOAJ |
| description | HIV infection results in the depletion of CD4+ T cells overtime and the loss of coordinated cellular immunity, but how this corresponds to the SIV infected African Green Monkey (AGM) model of non-progressive disease is not known. Here the authors assess the impact of experimental CD4+ T cell depletion in AGM and show that lack of disease progression and resistance to AIDS in this model are independent of CD4+ T cell loss. |
| first_indexed | 2024-04-09T22:47:54Z |
| format | Article |
| id | doaj.art-3fb3a179a4c24353b99b12d1f312421c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:47:54Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3fb3a179a4c24353b99b12d1f312421c2023-03-22T11:45:15ZengNature PortfolioNature Communications2041-17232023-02-0114111710.1038/s41467-023-36379-2Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeysQuentin Le Hingrat0Paola Sette1Cuiling Xu2Andrew R. Rahmberg3Lilas Tarnus4Haritha Annapureddy5Adam Kleinman6Egidio Brocca-Cofano7Ranjit Sivanandham8Sindhuja Sivanandham9Tianyu He10Daniel J. Capreri11Dongzhu Ma12Jacob D. Estes13Jason M. Brenchley14Cristian Apetrei15Ivona Pandrea16Department of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghBarrier Immunity Section, Lab of Viral Diseases, Division of Intramural Research, NIAID, NIHDepartment of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghVaccine and Gene Therapy Institute, Oregon Health & Science UniversityBarrier Immunity Section, Lab of Viral Diseases, Division of Intramural Research, NIAID, NIHDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of PittsburghDepartment of Pathology, School of Medicine, University of PittsburghHIV infection results in the depletion of CD4+ T cells overtime and the loss of coordinated cellular immunity, but how this corresponds to the SIV infected African Green Monkey (AGM) model of non-progressive disease is not known. Here the authors assess the impact of experimental CD4+ T cell depletion in AGM and show that lack of disease progression and resistance to AIDS in this model are independent of CD4+ T cell loss.https://doi.org/10.1038/s41467-023-36379-2 |
| spellingShingle | Quentin Le Hingrat Paola Sette Cuiling Xu Andrew R. Rahmberg Lilas Tarnus Haritha Annapureddy Adam Kleinman Egidio Brocca-Cofano Ranjit Sivanandham Sindhuja Sivanandham Tianyu He Daniel J. Capreri Dongzhu Ma Jacob D. Estes Jason M. Brenchley Cristian Apetrei Ivona Pandrea Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys Nature Communications |
| title | Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys |
| title_full | Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys |
| title_fullStr | Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys |
| title_full_unstemmed | Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys |
| title_short | Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys |
| title_sort | prolonged experimental cd4 t cell depletion does not cause disease progression in siv infected african green monkeys |
| url | https://doi.org/10.1038/s41467-023-36379-2 |
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