Dihydroxyphenylacetaldehyde Lowering Treatment Improves Locomotor and Neurochemical Abnormalities in the Rat Rotenone Model: Relevance to the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease

Dihydroxyphenylacetaldehyde Lowering Treatment Improves Locomotor and Neurochemical Abnormalities in the Rat Rotenone Model: Relevance to the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease

The catecholaldehyde hypothesis for the pathogenesis of Parkinson’s disease centers on accumulation of 3,4-dihydroxyphenylacetaldehyde (DOPAL) in dopaminergic neurons. To test the hypothesis, it is necessary to reduce DOPAL and assess if this improves locomotor abnormalities. Systemic administration...

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Bibliographic Details
Main Authors: Rawan Khashab, Naama Gutman-Sharabi, Zehava Shabtai, Regev Landau, Reut Halperin, Tsviya Fay-Karmon, Avshalom Leibowitz, Yehonatan Sharabi
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
DOPAL
catecholaldehydes
monoaminoxidase inhibitor
n-acetylcysteine
Online Access:https://www.mdpi.com/1422-0067/24/15/12522

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https://www.mdpi.com/1422-0067/24/15/12522

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