Artemisinin derivatives induce oxidative stress leading to DNA damage and caspase-mediated apoptosis in Theileria annulata-transformed cells

Artemisinin derivatives induce oxidative stress leading to DNA damage and caspase-mediated apoptosis in Theileria annulata-transformed cells

Abstract Background Bovine theileriosis caused by the eukaryotic parasite Theileria annulata is an economically important tick-borne disease. If it is not treated promptly, this lymphoproliferative disease has a significant fatality rate. Buparvaquone (BPQ) is the only chemotherapy-based treatment a...

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Bibliographic Details
Main Authors: Madhumanti Barman, Debabrata Dandasena, Akash Suresh, Vasundhra Bhandari, Sonam Kamble, Sakshi Singh, Madhusmita Subudhi, Paresh Sharma
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cell Communication and Signaling
Subjects:
Artemisinin
Drug repurposing
Oxidative DNA damage
DNA double-stranded breaks
Apoptosis
Apicomplexan
Online Access:https://doi.org/10.1186/s12964-023-01067-7

Internet

https://doi.org/10.1186/s12964-023-01067-7

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