Synthesis, biological evaluation and docking of novel bisamidinohydrazones as NON-peptide inhibitors of furin
A series of novel non-peptidic furin inhibitors with values of inhibitory constants (Ki) in the range of 0.74-1.54 μM was obtained by interactions of aminoguanidine hydrocarbonate with three diaryldicarbaldehydes. Correspondingly p-hydroquinone, piperazine and adipic acid were used as linkers betwee...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-02-01
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| Series: | The Ukrainian Biochemical Journal |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Kibirev_1_15.pdf |