Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?

HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molec...

Полное описание

Библиографические подробности
Главные авторы: Philip Mwimanzi, Tristan J. Markle, Mark A. Brockman, Takamasa Ueno
Формат: Статья
Язык:English
Опубликовано: MDPI AG 2012-09-01
Серии:Viruses
Предметы:
Online-ссылка:http://www.mdpi.com/1999-4915/4/9/1711