Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?
HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molec...
Главные авторы: | , , , |
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Формат: | Статья |
Язык: | English |
Опубликовано: |
MDPI AG
2012-09-01
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Серии: | Viruses |
Предметы: | |
Online-ссылка: | http://www.mdpi.com/1999-4915/4/9/1711 |