Presynaptic 5-HT<sub>2A</sub>-mGlu2/3 Receptor–Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis

Presynaptic 5-HT<sub>2A</sub>-mGlu2/3 Receptor–Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis

The glutamatergic nerve endings of a rat prefrontal cortex (PFc) possess presynaptic 5-HT<sub>2A</sub> heteroreceptors and mGlu2/3 autoreceptors, whose activation inhibits glutamate exocytosis, and is measured as 15 mM KCl-evoked [<sup>3</sup>H]D-aspartate ([<sup>3</...

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Bibliographic Details
Main Authors: Alice Taddeucci, Guendalina Olivero, Alessandra Roggeri, Claudio Milanese, Francesco Paolo Di Giorgio, Massimo Grilli, Mario Marchi, Beatrice Garrone, Anna Pittaluga
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
synaptosomes
mGlu2/3 receptor
5-HT<sub>2A</sub> receptor
glutamate exocytosis
trazodone
prefrontal cortex
Online Access:https://www.mdpi.com/2073-4409/11/19/3035

Internet

https://www.mdpi.com/2073-4409/11/19/3035

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