Loss of Frizzled 9 in Lung Cells Alters Epithelial Phenotype and Promotes Premalignant Lesion Development

Loss of Frizzled 9 in Lung Cells Alters Epithelial Phenotype and Promotes Premalignant Lesion Development

The transmembrane receptor Frizzled 9 (FZD9) is important for fetal neurologic and bone development through both canonical and non-canonical WNT/FZD signaling. In the adult lung, however, Fzd9 helps to maintain a normal epithelium by signaling through peroxisome proliferator activated receptor γ (PP...

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Bibliographic Details
Main Authors: Kayla Sompel, Lori D. Dwyer-Nield, Alex J. Smith, Alamelu P. Elango, Lauren A. Vanderlinden, Katrina Kopf, Robert L. Keith, Meredith A. Tennis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
Frizzled 9
lung cancer
transformed growth
EMT
premalignant lesions
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.815737/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.815737/full

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