Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl<sup>−</sup>/H<sup>+</sup> Antiporter

Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl<sup>−</sup>/H<sup>+</sup> Antiporter

Intracellular transport of chloride by members of the CLC transporter family involves a coupled exchange between a Cl<sup>−</sup> anion and a proton (H<sup>+</sup>), which makes the transport function dependent on ambient pH. Transport activity peaks at pH 4.5 and stalls at n...

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Bibliographic Details
Main Authors: Ekaterina Kots, Derek M. Shore, Harel Weinstein
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
CLC transporters
pH-dependent activity
molecular dynamics (MD) simulations
high-resolution atomic force microscopy (HR-AFM)
protonation state representations
net charge conservation protocol
Online Access:https://www.mdpi.com/1420-3049/26/22/6956

Internet

https://www.mdpi.com/1420-3049/26/22/6956

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