Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium

Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium

It is unclear why hemorrhagic myocardial infarctions (hMI) are destined for adverse outcomes. Here, the authors show that hMI drives fatty degeneration of infarct territories and contributes to adverse remodeling of the heart, which can be mitigated via timely depletion of iron within the hMI zone.

Bibliographic Details
Main Authors: Ivan Cokic, Shing Fai Chan, Xingmin Guan, Anand R. Nair, Hsin-Jung Yang, Ting Liu, Yinyin Chen, Diego Hernando, Jane Sykes, Richard Tang, John Butler, Alice Dohnalkova, Libor Kovarik, Robert Finney, Avinash Kali, Behzad Sharif, Louis S. Bouchard, Rajesh Gupta, Mayil Singaram Krishnam, Keyur Vora, Balaji Tamarappoo, Andrew G. Howarth, Andreas Kumar, Joseph Francis, Scott B. Reeder, John C. Wood, Frank S. Prato, Rohan Dharmakumar
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33776-x

Internet

https://doi.org/10.1038/s41467-022-33776-x

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