Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium
It is unclear why hemorrhagic myocardial infarctions (hMI) are destined for adverse outcomes. Here, the authors show that hMI drives fatty degeneration of infarct territories and contributes to adverse remodeling of the heart, which can be mitigated via timely depletion of iron within the hMI zone.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33776-x |
| _version_ | 1811197815451287552 |
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| author | Ivan Cokic Shing Fai Chan Xingmin Guan Anand R. Nair Hsin-Jung Yang Ting Liu Yinyin Chen Diego Hernando Jane Sykes Richard Tang John Butler Alice Dohnalkova Libor Kovarik Robert Finney Avinash Kali Behzad Sharif Louis S. Bouchard Rajesh Gupta Mayil Singaram Krishnam Keyur Vora Balaji Tamarappoo Andrew G. Howarth Andreas Kumar Joseph Francis Scott B. Reeder John C. Wood Frank S. Prato Rohan Dharmakumar |
| author_facet | Ivan Cokic Shing Fai Chan Xingmin Guan Anand R. Nair Hsin-Jung Yang Ting Liu Yinyin Chen Diego Hernando Jane Sykes Richard Tang John Butler Alice Dohnalkova Libor Kovarik Robert Finney Avinash Kali Behzad Sharif Louis S. Bouchard Rajesh Gupta Mayil Singaram Krishnam Keyur Vora Balaji Tamarappoo Andrew G. Howarth Andreas Kumar Joseph Francis Scott B. Reeder John C. Wood Frank S. Prato Rohan Dharmakumar |
| author_sort | Ivan Cokic |
| collection | DOAJ |
| description | It is unclear why hemorrhagic myocardial infarctions (hMI) are destined for adverse outcomes. Here, the authors show that hMI drives fatty degeneration of infarct territories and contributes to adverse remodeling of the heart, which can be mitigated via timely depletion of iron within the hMI zone. |
| first_indexed | 2024-04-12T01:20:48Z |
| format | Article |
| id | doaj.art-3fcbb124b97648aaa977eecd97230304 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T01:20:48Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3fcbb124b97648aaa977eecd972303042022-12-22T03:53:48ZengNature PortfolioNature Communications2041-17232022-10-0113111810.1038/s41467-022-33776-xIntramyocardial hemorrhage drives fatty degeneration of infarcted myocardiumIvan Cokic0Shing Fai Chan1Xingmin Guan2Anand R. Nair3Hsin-Jung Yang4Ting Liu5Yinyin Chen6Diego Hernando7Jane Sykes8Richard Tang9John Butler10Alice Dohnalkova11Libor Kovarik12Robert Finney13Avinash Kali14Behzad Sharif15Louis S. Bouchard16Rajesh Gupta17Mayil Singaram Krishnam18Keyur Vora19Balaji Tamarappoo20Andrew G. Howarth21Andreas Kumar22Joseph Francis23Scott B. Reeder24John C. Wood25Frank S. Prato26Rohan Dharmakumar27Cedars-Sinai Medical CenterKrannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular InstituteKrannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular InstituteCedars-Sinai Medical CenterCedars-Sinai Medical CenterCedars-Sinai Medical CenterCedars-Sinai Medical CenterUniversity of WisconsinLawson Health Research Institute, University of Western OntarioKrannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular InstituteLawson Health Research Institute, University of Western OntarioPacific Northwest National LaboratoryPacific Northwest National LaboratoryCardio-TheranosticsCedars-Sinai Medical CenterKrannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular InstituteUniversity of CaliforniaUniversity of ToledoStanford UniversityKrannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular InstituteKrannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular InstituteUniversity of CalgaryNorthern Ontario School of MedicineLouisiana State UniversityUniversity of WisconsinUniversity of Southern CaliforniaLawson Health Research Institute, University of Western OntarioKrannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular InstituteIt is unclear why hemorrhagic myocardial infarctions (hMI) are destined for adverse outcomes. Here, the authors show that hMI drives fatty degeneration of infarct territories and contributes to adverse remodeling of the heart, which can be mitigated via timely depletion of iron within the hMI zone.https://doi.org/10.1038/s41467-022-33776-x |
| spellingShingle | Ivan Cokic Shing Fai Chan Xingmin Guan Anand R. Nair Hsin-Jung Yang Ting Liu Yinyin Chen Diego Hernando Jane Sykes Richard Tang John Butler Alice Dohnalkova Libor Kovarik Robert Finney Avinash Kali Behzad Sharif Louis S. Bouchard Rajesh Gupta Mayil Singaram Krishnam Keyur Vora Balaji Tamarappoo Andrew G. Howarth Andreas Kumar Joseph Francis Scott B. Reeder John C. Wood Frank S. Prato Rohan Dharmakumar Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium Nature Communications |
| title | Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium |
| title_full | Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium |
| title_fullStr | Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium |
| title_full_unstemmed | Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium |
| title_short | Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium |
| title_sort | intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium |
| url | https://doi.org/10.1038/s41467-022-33776-x |
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