Efficient Consecutive Synthesis of Ethyl-2-(4-Aminophenoxy) Acetate, a Precursor for Dual GK and PPARγ Activators, X-ray Structure, Hirshfeld Analysis, and DFT Studies

Efficient Consecutive Synthesis of Ethyl-2-(4-Aminophenoxy) Acetate, a Precursor for Dual GK and PPARγ Activators, X-ray Structure, Hirshfeld Analysis, and DFT Studies

Herein, we report a facile synthesis of ethyl-2-(4-aminophenoxy)acetate <b>4</b> as a building synthon for novel dual hypoglycemic agents. This building template was synthesized by alkylation of 4-nitrophenol with ethyl bromo-acetate followed by selective reduction of the nitro group. Th...

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Bibliographic Details
Main Authors: Mezna Saleh Altowyan, Saied M. Soliman, Magda M. F. Ismail, Matti Haukka, Assem Barakat, Mohammed Salah Ayoup
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Crystals
Subjects:
aminophenoxy
consecutive reaction
hypoglycemic
X-ray
Hirshfeld analysis
Online Access:https://www.mdpi.com/2073-4352/12/2/227

Internet

https://www.mdpi.com/2073-4352/12/2/227

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