Efficient Consecutive Synthesis of Ethyl-2-(4-Aminophenoxy) Acetate, a Precursor for Dual GK and PPARγ Activators, X-ray Structure, Hirshfeld Analysis, and DFT Studies
Herein, we report a facile synthesis of ethyl-2-(4-aminophenoxy)acetate <b>4</b> as a building synthon for novel dual hypoglycemic agents. This building template was synthesized by alkylation of 4-nitrophenol with ethyl bromo-acetate followed by selective reduction of the nitro group. Th...
Main Authors: | Mezna Saleh Altowyan, Saied M. Soliman, Magda M. F. Ismail, Matti Haukka, Assem Barakat, Mohammed Salah Ayoup |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-02-01
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Series: | Crystals |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4352/12/2/227 |
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