Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner

Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner

The cystine/glutamate antiporter xCT is an important source of cysteine for cancer cells. Once taken up, cystine is reduced to cysteine and serves as a building block for the synthesis of glutathione, which efficiently protects cells from oxidative damage and prevents ferroptosis. As melanomas are p...

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Bibliographic Details
Main Authors: Madlen Meinert, Christina Jessen, Anita Hufnagel, Julia Katharina Charlotte Kreß, Mychal Burnworth, Theo Däubler, Till Gallasch, Thamara Nishida Xavier da Silva, Ancély Ferreira dos Santos, Carsten Patrick Ade, Werner Schmitz, Susanne Kneitz, José Pedro Friedmann Angeli, Svenja Meierjohann
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723004123

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http://www.sciencedirect.com/science/article/pii/S2213231723004123

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