Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function

Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function

Radiation therapy is a standard treatment for head and neck tumors. However, patients often exhibit cognitive impairments following radiation therapy. Previous studies have revealed that hippocampal dysfunction, specifically abnormal hippocampal neurogenesis or neuroinflammation, plays a key role in...

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Bibliographic Details
Main Authors: Min-Yi Wu, Wen-Jun Zou, Pei Yu, Yuhua Yang, Shao-Jian Li, Qiang Liu, Jiatian Xie, Si-Qi Chen, Wei-Jye Lin, Yamei Tang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
gaba-mediated hyperfunction; glur; intrinsic excitability; long-term potentiation; radiation-induced cognitive impairment; spontaneous excitatory postsynaptic currents; spontaneous inhibitory postsynaptic currents; synaptic plasticity; type i vesicular glutamate transporter; vesicular gaba transporter; whole-cell patch clamp recording
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=10;spage=2253;epage=2259;aulast=Wu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=10;spage=2253;epage=2259;aulast=Wu

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