Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function
Radiation therapy is a standard treatment for head and neck tumors. However, patients often exhibit cognitive impairments following radiation therapy. Previous studies have revealed that hippocampal dysfunction, specifically abnormal hippocampal neurogenesis or neuroinflammation, plays a key role in...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=10;spage=2253;epage=2259;aulast=Wu |
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| author | Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang |
| author_facet | Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang |
| author_sort | Min-Yi Wu |
| collection | DOAJ |
| description | Radiation therapy is a standard treatment for head and neck tumors. However, patients often exhibit cognitive impairments following radiation therapy. Previous studies have revealed that hippocampal dysfunction, specifically abnormal hippocampal neurogenesis or neuroinflammation, plays a key role in radiation-induced cognitive impairment. However, the long-term effects of radiation with respect to the electrophysiological adaptation of hippocampal neurons remain poorly characterized. We found that mice exhibited cognitive impairment 3 months after undergoing 10 minutes of cranial irradiation at a dose rate of 3 Gy/min. Furthermore, we observed a remarkable reduction in spike firing and excitatory synaptic input, as well as greatly enhanced inhibitory inputs, in hippocampal CA1 pyramidal neurons. Corresponding to the electrophysiological adaptation, we found reduced expression of synaptic plasticity marker VGLUT1 and increased expression of VGAT. Furthermore, in irradiated mice, long-term potentiation in the hippocampus was weakened and GluR1 expression was inhibited. These findings suggest that radiation can impair intrinsic excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons. |
| first_indexed | 2024-04-13T19:10:06Z |
| format | Article |
| id | doaj.art-3fd46700f7a84fbda2d36eb73af59fb9 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-13T19:10:06Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-3fd46700f7a84fbda2d36eb73af59fb92022-12-22T02:33:51ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-0117102253225910.4103/1673-5374.336875Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive functionMin-Yi WuWen-Jun ZouPei YuYuhua YangShao-Jian LiQiang LiuJiatian XieSi-Qi ChenWei-Jye LinYamei TangRadiation therapy is a standard treatment for head and neck tumors. However, patients often exhibit cognitive impairments following radiation therapy. Previous studies have revealed that hippocampal dysfunction, specifically abnormal hippocampal neurogenesis or neuroinflammation, plays a key role in radiation-induced cognitive impairment. However, the long-term effects of radiation with respect to the electrophysiological adaptation of hippocampal neurons remain poorly characterized. We found that mice exhibited cognitive impairment 3 months after undergoing 10 minutes of cranial irradiation at a dose rate of 3 Gy/min. Furthermore, we observed a remarkable reduction in spike firing and excitatory synaptic input, as well as greatly enhanced inhibitory inputs, in hippocampal CA1 pyramidal neurons. Corresponding to the electrophysiological adaptation, we found reduced expression of synaptic plasticity marker VGLUT1 and increased expression of VGAT. Furthermore, in irradiated mice, long-term potentiation in the hippocampus was weakened and GluR1 expression was inhibited. These findings suggest that radiation can impair intrinsic excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=10;spage=2253;epage=2259;aulast=Wugaba-mediated hyperfunction; glur; intrinsic excitability; long-term potentiation; radiation-induced cognitive impairment; spontaneous excitatory postsynaptic currents; spontaneous inhibitory postsynaptic currents; synaptic plasticity; type i vesicular glutamate transporter; vesicular gaba transporter; whole-cell patch clamp recording |
| spellingShingle | Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function Neural Regeneration Research gaba-mediated hyperfunction; glur; intrinsic excitability; long-term potentiation; radiation-induced cognitive impairment; spontaneous excitatory postsynaptic currents; spontaneous inhibitory postsynaptic currents; synaptic plasticity; type i vesicular glutamate transporter; vesicular gaba transporter; whole-cell patch clamp recording |
| title | Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function |
| title_full | Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function |
| title_fullStr | Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function |
| title_full_unstemmed | Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function |
| title_short | Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function |
| title_sort | cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal ca1 pyramidal neurons with implications for cognitive function |
| topic | gaba-mediated hyperfunction; glur; intrinsic excitability; long-term potentiation; radiation-induced cognitive impairment; spontaneous excitatory postsynaptic currents; spontaneous inhibitory postsynaptic currents; synaptic plasticity; type i vesicular glutamate transporter; vesicular gaba transporter; whole-cell patch clamp recording |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=10;spage=2253;epage=2259;aulast=Wu |
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