Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 Infection

Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 Infection

Fc-mediated virus entry has been observed for many viruses, but the characterization of this activity in convalescent plasma against SARS-CoV-2 Variants of Concern (VOC) is undefined. In this study, we evaluated Fc-mediated viral entry (FVE) on FcγRIIa-expressing HEK293 cells in the presence of SARS...

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Bibliographic Details
Main Authors: Lindsay Wieczorek, Michelle Zemil, Mélanie Merbah, Vincent Dussupt, Erin Kavusak, Sebastian Molnar, Jonah Heller, Bradley Beckman, Suzanne Wollen-Roberts, Kristina K. Peachman, Janice M. Darden, Shelly Krebs, Morgane Rolland, Sheila A. Peel, Victoria R. Polonis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
coronavirus – COVID-19
variant of concern
antibody dependent enhancement
neutralization
pseudovirus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.901217/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.901217/full

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