First-in-human autologous oral mucosal epithelial sheet transplantation to prevent anastomotic re-stenosis in congenital esophageal atresia

First-in-human autologous oral mucosal epithelial sheet transplantation to prevent anastomotic re-stenosis in congenital esophageal atresia

Abstract Background Congenital esophageal atresia postoperative anastomotic stricture occurs in 30–50% of cases. Patients with severe dysphagia are treated with endoscopic balloon dilatation (EBD) and/or local injection of steroids, but many patients continue to experience frequent stricture. In thi...

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Bibliographic Details
Main Authors: Akihiro Fujino, Yasushi Fuchimoto, Yoshiyuki Baba, Nobutaka Isogawa, Takanori Iwata, Katsuhiro Arai, Makoto Abe, Nobuo Kanai, Ryo Takagi, Masanori Maeda, Akihiro Umezawa
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Stem Cell Research & Therapy
Subjects:
Congenital esophageal atresia
Anastomotic stenosis
Epithelial cell sheet
Cell sheet transplantation
Somatic stem cells
Regenerative therapy
Online Access:https://doi.org/10.1186/s13287-022-02710-9

Internet

https://doi.org/10.1186/s13287-022-02710-9

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