Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata

Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata

ABSTRACT Candida glabrata is poised to adapt to drug pressure rapidly and acquire antifungal resistance leading to therapeutic failure. Given the limited antifungal armamentarium, there is an unmet need to explore new targets or therapeutic strategies for antifungal treatment. The lysine acetyltrans...

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Bibliographic Details
Main Authors: Shuying Yu, Padmaja Paderu, Annie Lee, Sami Eirekat, Kelley Healey, Liang Chen, David S. Perlin, Yanan Zhao
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
Candida glabrata
GCN5
antifungal resistance
virulence
transcriptomics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00963-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00963-22

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