Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Abstract Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects. We therefore tested the hypothesis that secretome of these cells might be used instead to still fo...

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Bibliographic Details
Main Authors: Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Mazurek, Fabien Gosselet
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Molecular Medicine
Subjects:
Brain microvascular endothelial cells
Secretome
Blood–brain barrier
Stroke
Angiogenesis
Cell therapy
Online Access:https://doi.org/10.1186/s10020-024-00897-6

Internet

https://doi.org/10.1186/s10020-024-00897-6

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