TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells

TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells

Abstract Background Tumor necrosis factor-alpha (TNF-α), one of the pro-inflammatory cytokines mediating the local inflammatory process in joints, inhibits cartilage formation and has a detrimental effect on stem cell-based cartilage regeneration for the treatment of osteoarthritis (OA). However, th...

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Bibliographic Details
Main Authors: Jiajia Guo, Wang Ye, Xinglin Wu, Haifeng Huang, Bo Li, Zeyu Sun, Zhijing Ren, Zhen Yang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
OPA1
Mitochondrial fusion
TNFRSF1B
RELA
Chondrogenic differentiation
Human adipose-derived stem cells
Online Access:https://doi.org/10.1186/s13018-023-03846-x

Internet

https://doi.org/10.1186/s13018-023-03846-x

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