The anticancer effects of Metformin in the male germ tumor SEM-1 cell line are mediated by HMGA1

The anticancer effects of Metformin in the male germ tumor SEM-1 cell line are mediated by HMGA1

IntroductionGerm cell tumors (GCTs) are the most common type of cancer in young men. These tumors usually originate from the testis, but they can occasionally develop from extragonadal sites probably due to primordial germ cells (PGCs) migration errors. Cisplatin-based chemotherapy is usually effect...

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Bibliographic Details
Main Authors: Alessandro Salatino, Maria Mirabelli, Eusebio Chiefari, Marta Greco, Anna Di Vito, Giuseppe Bonapace, Francesco S. Brunetti, Fabio Crocerossa, Alan L. Epstein, Daniela P. Foti, Antonio Brunetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
Metformin
germ cell tumors
IGFBP1
HMGA1
SEM-1 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1051988/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1051988/full

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