ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin

ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin

Summary: β-Hemoglobinopathies can trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin. However, the mechanisms underlying γ-globin production during cellular str...

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Bibliographic Details
Main Authors: Mandy Y. Boontanrart, Markus S. Schröder, Gautier M. Stehli, Marija Banović, Stacia K. Wyman, Rachel J. Lew, Matteo Bordi, Benjamin G. Gowen, Mark A. DeWitt, Jacob E. Corn
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
Fetal hemoglobin
adult hemoglobin
stress erythropoiesis
BCL11A
HBS1L-MYB
hemoglobinopathies
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309785

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http://www.sciencedirect.com/science/article/pii/S2211124720309785

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