Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy

Arrhythmogenic cardiomyopathy is a genetically inherited disease caused by deletion of an arginine in Phospholamban (PLN), a small protein that regulates intracellular calcium levels. Here the authors show that zebrafish with the PLN p.Arg14del mutation develop severe cardiomyopathy which is precede...

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Bibliographic Details
Main Authors: S. M. Kamel, C. J. M. van Opbergen, C. D. Koopman, A. O. Verkerk, B. J. D. Boukens, B. de Jonge, Y. L. Onderwater, E. van Alebeek, S. Chocron, C. Polidoro Pontalti, W. J. Weuring, M. A. Vos, T. P. de Boer, T. A. B. van Veen, J. Bakkers
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27461-8

Internet

https://doi.org/10.1038/s41467-021-27461-8

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