G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer

G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer

SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenesis.

Bibliographic Details
Main Authors: Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian. D. Robinson, Arul M. Chinnaiyan, Mark A. Rubin, Christopher E. Barbieri, Pengbo Zhou
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27024-x

Internet

https://doi.org/10.1038/s41467-021-27024-x

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