Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer

Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer

The DNA damage response (DDR) is critical for maintaining genome stability, and abnormal DDR—resulting from mutations in DNA damage-sensing and repair proteins—is a hallmark of cancer. Here, we aimed to investigate the predictive power of DDR gene mutations and the tumor mutational load (TML) for su...

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Bibliographic Details
Main Authors: Vincent Ho, Liping Chung, Stephanie H. Lim, Yafeng Ma, Bin Wang, Vivienne Lea, Askar Abubakar, Weng Ng, Mark Lee, Tara L. Roberts, Wei Chua, C. Soon Lee
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Gastrointestinal Disorders
Subjects:
DNA damage response (DDR)
colorectal cancer (CRC)
mismatch repair (MMR)
neoadjuvant chemo/radiotherapy
next-generation sequencing (NGS)
tumor mutational load (TML)
Online Access:https://www.mdpi.com/2624-5647/4/3/16

Internet

https://www.mdpi.com/2624-5647/4/3/16

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