Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H<sup>+</sup>-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation

Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H<sup>+</sup>-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation

The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac function. Additionally, diabetes is accompanied b...

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Bibliographic Details
Main Authors: Shujin Wang, Dietbert Neumann, B. Daan Westenbrink, Francesco Schianchi, Li-Yen Wong, Aomin Sun, Agnieszka Strzelecka, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
ketone bodies
vacuolar-type H+-ATPase
endosomal CD36
lipid-induced insulin resistance
contractile function
diabetic heart
Online Access:https://www.mdpi.com/1422-0067/23/21/12909

Internet

https://www.mdpi.com/1422-0067/23/21/12909

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