Hexamethylene amiloride synergizes with venetoclax to induce lysosome-dependent cell death in acute myeloid leukemia

Hexamethylene amiloride synergizes with venetoclax to induce lysosome-dependent cell death in acute myeloid leukemia

Summary: Tumors maintain an alkaline intracellular environment to enable rapid growth. The proton exporter NHE1 participates in maintenance of this pH gradient. However, whether targeting NHE1 could inhibit the growth of tumor cells remains unknown. Here, we report that the NHE1 inhibitor Hexamethyl...

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Bibliographic Details
Main Authors: Xinya Jiang, Kexiu Huang, Xiaofan Sun, Yue Li, Lei Hua, Fangshu Liu, Rui Huang, Juan Du, Hui Zeng
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Cancer
Cell biology
Cellular toxicology
Molecular medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223027682

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http://www.sciencedirect.com/science/article/pii/S2589004223027682

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