Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways

Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways

Cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX) are overexpressed in gastric cancer cells, the dual inhibitors of which exhibit potential against metastasis and invasion with fewer side effects. To discover inhibitors targeting COX-2 and 5-LOX, we conducted ultrafiltration and enrichment calcula...

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Bibliographic Details
Main Authors: Yong-Qiang Tian, Jing Liu, Peng Cheng, Jian Zou, Hui-Fang Xu, Xin-Hua Shi, Yi-Sheng Zhang, Ling Mei
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Chemistry
Subjects:
Zanthoxylum simulans
ultrafiltration
COX-2 inhibitors
5-LOX inhibitors
gastric cancer cells
hormone pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1287570/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2023.1287570/full

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