Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response

Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response

Introduction: Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model for human filarial infections. Methods: Utiliz...

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Bibliographic Details
Main Authors: Cécile Guth, Pia Philippa Schumacher, Archena Vijayakumar, Hannah Borgmann, Helene Balles, Marianne Koschel, Frederic Risch, Benjamin Lenz, Achim Hoerauf, Marc P. Hübner, Jesuthas Ajendra
Format: Article
Language:English
Published: Karger Publishers 2024-02-01
Series:Journal of Innate Immunity
Subjects:
eosinophils
interleukin-4
nematode infection
cd4+ t cells
macrophages
Online Access:https://beta.karger.com/Article/FullText/536357

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https://beta.karger.com/Article/FullText/536357

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