The efficient synthesis and purification of 2′3’- cGAMP from Escherichia coli

Agonists of the stimulator of interferon genes (STING) pathway are being explored as potential immunotherapeutics for the treatment of cancer and as vaccine adjuvants for infectious diseases. Although chemical synthesis of 2′3’ - cyclic Guanosine Monophosphate–Adenosine Monophosphate (cGAMP) is comm...

Full description

Bibliographic Details
Main Authors: Rohan Kulkarni, Vijay Maranholkar, Nam Nguyen, Patrick C. Cirino, Richard C. Willson, Navin Varadarajan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1345617/full