Replacement of the Mouse LD<sub>50</sub> Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Replacement of the Mouse LD<sub>50</sub> Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Botulinum neurotoxins (BoNTs) are important therapeutic agents. The in vivo median lethal dose (LD<sub>50</sub>) assay has been commonly used to measure the potency of BoNT commercial preparations. As an alternative, we developed cell-based assays for abobotulinumtoxinA in both powder (D...

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Bibliographic Details
Main Authors: Elena Fonfria, Elizabeth Marks, Lisa-Marie Foulkes, Rebecca Schofield, Daniel Higazi, Sam Coward, Alistair Kippen
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Toxins
Subjects:
botulinum
toxin
LD<sub>50</sub>
CBA
potency
replacement
Online Access:https://www.mdpi.com/2072-6651/15/5/314

Internet

https://www.mdpi.com/2072-6651/15/5/314

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