Deciphering the antigen specificities of antibodies by clustering their complementarity determining region sequences

Deciphering the antigen specificities of antibodies by clustering their complementarity determining region sequences

ABSTRACTRecent advances in adaptive immune receptor repertoire sequencing have provided abundant B cell receptor (BCR) sequences under various conditions, including vaccination and disease. However, determining target antigen and epitope specificity of the corresponding antibodies is a major challen...

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Bibliographic Details
Main Authors: Dianita S. Saputri, Hendra S. Ismanto, Dendi K. Nugraha, Zichang Xu, Yasuhiko Horiguchi, Shuhei Sakakibara, Daron M. Standley
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mSystems
Subjects:
antibody
antigen-specific
B cell receptor
clustering
diphtheria
pertussis
Online Access:https://journals.asm.org/doi/10.1128/msystems.00722-23

Internet

https://journals.asm.org/doi/10.1128/msystems.00722-23

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