Altered functional responses by PAR1 agonist in murine dextran sodium sulphate-treated colon

Abstract Protease-activated receptor-1 (PAR1) is highly expressed in murine colonic smooth muscles. Responses to PAR1 activation are complex and result from responses in multiple cell types. We investigated whether PAR1 responses are altered in inflamed colon induced by dextran sodium sulfate (DSS)-...

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Bibliographic Details
Main Authors: Tae Sik Sung, Suk Bae Moon, Brian A. Perrino, Kenton M. Sanders, Sang Don Koh
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-21285-2