Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies

Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies

Abstract Background Accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including Alzheimer’s disease. As the disease progresses, there is a decline in brain energy metabolism. However, the role of tau protein in regulating lipid metabolism remains less characteriz...

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Bibliographic Details
Main Authors: Dominika Olešová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký, Andrej Kováč
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Neuroinflammation
Subjects:
Tau protein
Neurodegeneration
Microglia
Lipidomics
Metabolomics
SHR24
Online Access:https://doi.org/10.1186/s12974-024-03060-4

Internet

https://doi.org/10.1186/s12974-024-03060-4

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