Glucagon Reduces Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice

Glucagon Reduces Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice

Sepsis is one of the most common comorbidities observed in diabetic patients, associated with a deficient innate immune response. Recently, we have shown that glucagon possesses anti-inflammatory properties. In this study, we investigated if hyperglucagonemia triggered by diabetes might reduce the m...

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Bibliographic Details
Main Authors: Daniella Bianchi Reis Insuela, Maximiliano Ruben Ferrero, Cassiano Felippe Gonçalves-de-Albuquerque, Amanda da Silva Chaves, Adriano Yagho Oliveira da Silva, Hugo Caire Castro-Faria-Neto, Rafael Loureiro Simões, Thereza Christina Barja-Fidalgo, Patricia Machado Rodrigues e Silva, Marco Aurélio Martins, Adriana Ribeiro Silva, Vinicius Frias Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
cAMP
diabetes
glucagon
neutrophil
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.633540/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.633540/full

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