Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Abstract Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylation at serine 1292 (pS1292) and neurotoxicity in model systems. pS1292-LRRK2 pr...

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Bibliographic Details
Main Authors: Shijie Wang, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Aasly, Andrew B. West
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Acta Neuropathologica Communications
Subjects:
Park8
dardarin
Neurodegeneration
Movement Disorders
Biomarkers
Microvesicles
Online Access:http://link.springer.com/article/10.1186/s40478-017-0492-y

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http://link.springer.com/article/10.1186/s40478-017-0492-y

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