Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c/ PPARα-NF-κB/IR-S2 signaling pathway

Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c/ PPARα-NF-κB/IR-S2 signaling pathway

Introduction: Nonalcoholic fatty liver disease (NAFLD) is a chronic disease characterized by fat deposits in liver cells, which can lead to hepatitis and fibrosis. This study attempted to explore the protective effect of vitamin D3 (VitD) against NAFLD.Methods: Adult male albino rats were randomized...

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Bibliographic Details
Main Authors: Doha Reda, Gehad E. Elshopakey, Talat A. Albukhari, Samah J. Almehmadi, Bassem Refaat, Engy F. Risha, Hebatallah A. Mahgoub, Mohamed E. El-Boshy, Fatma M. Abdelhamid
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
hepatic steatosis
vitamin D
high-fat diet
insulin resistance
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1164512/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1164512/full

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