Activation of GPR81 lactate receptors stimulates mitochondrial biogenesis in cerebral microvessel endothelial cells

Activation of GPR81 lactate receptors stimulates mitochondrial biogenesis in cerebral microvessel endothelial cells

Introduction. Cerebral endothelial cells express monocarboxylate transporters MCT1 for bloodbrain barrier (BBB) transfer of lactate, which are regulated by CD147 activity, as well as lactate receptors GPR81 (HCAR1). Metabolism and intercellular transport of lactate is the crucial mechanism for regul...

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Bibliographic Details
Main Authors: E. D. Khilazheva, N. V. Pisareva, A. V. Morgun, E. B. Boitsova, T. E. Taranushenko, O. V. Frolova, Alla B. Salmina
Format: Article
Language:English
Published: Research Center of Neurology 2017-05-01
Series:Анналы клинической и экспериментальной неврологии
Subjects:
cerebral endothelium
brain–blood barrier
mitochondria
lactate receptors
glycolysis
Online Access:https://annaly-nevrologii.com/journal/pathID/article/viewFile/457/351

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https://annaly-nevrologii.com/journal/pathID/article/viewFile/457/351

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