Impact of a Single Nucleotide Polymorphism on the 3D Protein Structure and Ubiquitination Activity of E3 Ubiquitin Ligase Arkadia

Impact of a Single Nucleotide Polymorphism on the 3D Protein Structure and Ubiquitination Activity of E3 Ubiquitin Ligase Arkadia

Single nucleotide polymorphisms (SNPs) are genetic variations which can play a vital role in the study of human health. SNP studies are often used to identify point mutations that are associated with diseases. Arkadia (RNF111) is an E3 ubiquitin ligase that enhances transforming growth factor-beta (...

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Bibliographic Details
Main Authors: Maria Birkou, Vasilios Raptis, Konstantinos D. Marousis, Athanasios Tsevis, Kyriakos Bourikas, Detlef Bentrop, Vasso Episkopou, Georgios A. Spyroulias
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
Arkadia
snps
NMR
RING
E3 ligase
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.844129/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.844129/full

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