Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins

Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins

Abstract Class B1 G protein-coupled receptors (GPCRs) are important regulators of many physiological functions such as glucose homeostasis, which is mainly mediated by three peptide hormones, i.e., glucagon-like peptide-1 (GLP-1), glucagon (GCG), and glucose-dependent insulinotropic polypeptide (GIP...

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Bibliographic Details
Main Authors: Zhaotong Cong, Fenghui Zhao, Yang Li, Gan Luo, Yiting Mai, Xianyue Chen, Yanyan Chen, Shi Lin, Xiaoqing Cai, Qingtong Zhou, Dehua Yang, Ming-Wei Wang
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00649-0

Internet

https://doi.org/10.1038/s41421-024-00649-0

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